Spider Bites – Wrap Up

Are spider bites dangerous? Many people are irrationally afraid of spiders. Arachnophobia is one of the most common phobias and can have a serious effect in some people, limiting their day-to-day activities.  Some evolutionary psychologists believe an instinctive fear of spiders is a residual survival technique passed down from our ancestors, while others argue that…

Calciphylaxis – Wrap Up

Another topic covered – and another quiz! In the latest short series of articles we have taken a brief look at the devastating condition known as calciphylaxis. Calciphylaxis is a condition that occurs predominantly in individuals with advanced chronic kidney disease, leading to vascular calcification, thrombosis, and skin necrosis. Lack of Treatment Options The pathophysiology…

Calciphylaxis – Diagnosis and Management

As we have seen in previous weeks, calciphylaxis is a severe and complex syndrome involving vascular calcification, thrombosis, and skin necrosis. Calciphylaxis occurs almost exclusively in patients with advanced chronic kidney disease (CKD), and has a dismal mortality rate of around 80 percent (with a 1-year mortality greater than 50 percent).(1) No Evidence-Based Medical Treatments…

Pathogenesis of Calciphylaxis

Calciphylaxis, a rare condition involving subcutaneous vascular calcification and cutaneous necrosis, is most commonly seen in patients with renal failure where it has a dismal mortality rate of up to 80 percent.(1) Calciphylaxis is a complex disorder associated with multiple histologic abnormalities and a multifactorial etiology.(1-3)  The exact pathogenesis of the condition is unclear, and…

Diagnosis of Necrotizing Fasciitis & Treatment

Diagnosis of necrotizing fasciitis (NF) can prove extremely challenging. The condition has many of the same characteristics as cellulitis, and is often diagnosed incorrectly as such.(1) The resulting delay in implementing appropriate treatment can prove catastrophic in such a rapidly progressing condition. Cellulitis or Necrotizing Fasciitis? One key differentiator between NF and cellulitis  is the…

Causes of Necrotizing Fasciitis & Risk Factors

Necrotizing fasciitis (NF), or the ‘flesh-eating bug’ as it tends to be known in the press, is an extremely rapidly progressing infection that is difficult to manage and can lead to significant morbidity and mortality. Risk Factors of Necrotizing Fasciitis While anyone with an infection may, in theory, develop NF, in practice the majority of…